Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 2003 Dec;28(12):646-54.

NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

Author information

  • 1Departments of Anesthesiology, Biochemistry and Molecular Genetics, and the UAB Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.


Tyrosine nitration is becoming increasingly recognized as a prevalent, functionally significant post-translational protein modification that serves as an indicator of nitric oxide (z.rad;NO)-mediated oxidative inflammatory reactions. Nitration of proteins modulates catalytic activity, cell signaling and cytoskeletal organization. Several reactions mediate protein nitration, and all predominantly depend on z.rad;NO- and nitrite-dependent formation of nitrogen dioxide, a species capable of nitrating aromatic amino acids, nucleotides and unsaturated fatty acids. Here, we review the mechanisms that mediate in vivo protein nitration and how nitration of specific tyrosine residues impacts on protein function.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk