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1: Genome Biol. 2003;4(12):241. Epub 2003 Nov 24.Click here to read Click here to read Links

Genetics and functional genomics of type 2 diabetes mellitus.

Toye A, Gauguier D.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1alpha. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.

PMID: 14659011 [PubMed - indexed for MEDLINE]

PMCID: PMC329413