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Genome Biol. 2003;4(12):122. Epub 2003 Nov 27.

Multi-species sequence comparison: the next frontier in genome annotation.

Author information

  • 1Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. ildubchak@lbl.gov

Abstract

Multi-species comparisons of DNA sequences are more powerful for discovering functional sequences than pairwise DNA sequence comparisons. Most current computational tools have been designed for pairwise comparisons, and efficient extension of these tools to multiple species will require knowledge of the ideal evolutionary distance to choose and the development of new algorithms for alignment, analysis of conservation, and visualization of results.

PMID:
14659006
[PubMed - indexed for MEDLINE]
PMCID:
PMC329408
Free PMC Article
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