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    J Org Chem. 2003 Dec 12;68(25):9648-53.

    Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.

    McMorris TC, Cong Q, Kelner MJ.

    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. tmcmorris@ucsd.edu

    Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

    PMID: 14656090 [PubMed - indexed for MEDLINE]

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