Your browser version may not work well with NCBI's Web applications. More information here...
1: J Org Chem. 2003 Dec 12;68(25):9648-53.Click here to read Links

Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. tmcmorris@ucsd.edu

Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

PMID: 14656090 [PubMed - indexed for MEDLINE]