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Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12028-32.

Wild-type p53 binds to the TATA-binding protein and represses transcription.

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  • 1Howard Hughes Medical Institute, Princeton University, NJ 08544-1014.


p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation.

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