Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Natl Cancer Inst. 2003 Dec 3;95(23):1747-57.

The epigenome as a target for cancer chemoprevention.

Author information

  • 1Chemopreventive Agent Development Research Group, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. kopelovl@mail.nih.gov


Epigenetic events, a key driving force in the development of cancer, are alterations in gene expression without changes in the DNA coding sequence that are heritable through cell division. Such changes occur throughout all stages of tumorigenesis, including the early phases, and are increasingly recognized as major mechanisms involved in silencing tumor suppressor genes. Epigenetic changes can be reversed by the use of small molecules and, thus, such changes are promising targets for cancer chemopreventive drug development. This review examines the basis for targeting the epigenome as a prevention strategy, focusing on understanding the epigenetic changes that occur before the development of frank malignancy, when chemopreventive intervention will have the maximal impact.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk