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Nat Cell Biol. 2003 Dec;5(12):1029-33.

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

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  • 1Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.


The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

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