Curr Opin Cell Biol. 2003 Dec;15(6):672-83.

Mitotic mechanics: the auroras come into view.

Andrews PD, Knatko E, Moore WJ, Swedlow JR.

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Division of Gene Expression and Regulation, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK.

Abstract

Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

PMID:: 14644191; [PubMed - indexed for MEDLINE]

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Cited by 57 PubMed Central articles

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