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Biochem Soc Trans. 2003 Dec;31(Pt 6):1232-7.

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

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  • 1School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, U.K.


Co-translational protein targeting to the endoplasmic reticulum requires the signal-recognition particle, its cognate receptor and the translocation channel. Co-ordination of the targeting process necessitates the interaction of these components with each other and with the ribosome. These interactions are regulated by three GTPases, which act in concert, ensuring the fidelity of the targeting process.

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