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Technol Cancer Res Treat. 2003 Dec;2(6):505-14.

Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.

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  • 1G.R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Ave., Bldg 6-014, Cambridge, MA 02139, USA.

Abstract

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

PMID:
14640762
[PubMed - indexed for MEDLINE]
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