Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2003 Dec;13(6):562-8.

Mutation rate variation in the mammalian genome.

Author information

  • 1Department of Evolutionary Biology, Uppsala University, Norbyv√§gen 18D, SE-752 36 Uppsala, Sweden. Hans.Ellegren@ebc.uu.se


Recent advances in the large-scale sequencing of mammalian genomes have provided a means to study divergence in not only genic sequences but also in the non-coding bulk of DNA. There is evidence of significant variation in the levels of divergence between presumably neutral regions, pointing at an underlying variation in the rate of mutation across the genome. Apparently, such variation occurs on different scales, including sequence context effects (the influence of neighboring nucleotides on the rate of mutation at individual sites), variation within chromosomes (on the scales of kilobases as well as megabases), and between chromosomes (among autosomes as well as between autosomes and sex chromosomes). An important aspect for further research in this area is to study whether there is an ultimate evolutionary explanation for mutation rate variation within mammalian genomes.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk