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Cell. 2003 Oct 31;115(3):251-3.

HtrA2/Omi, a sheep in wolf's clothing.

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  • 1The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, 3050, Victoria, Australia

Abstract

Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.

PMID:
14636553
[PubMed - indexed for MEDLINE]
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