Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2003 Oct 31;115(3):251-3.

HtrA2/Omi, a sheep in wolf's clothing.

Author information

  • 1The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, 3050, Victoria, Australia


Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk