Immunol Today. 1992 Dec;13(12):507-12.

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view.

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Section of Physiology, Brown University, Providence, RI 02912.

Abstract

This new view of the immunoreactivity of the normal brain is based on three key components. First, there is an active and highly-regulated communication between the brain and the central immune organs. Secondly, the connection from the brain to the draining nodes is much larger than previously appreciated. And third, the blood-brain barrier, by virtue of its selective permeability properties, contributes to the regulation of immunoregulatory cells and molecules in the brain cell microenvironment.

PMID:: 1463583; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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NS-11050/NS/NINDS NIH HHS/United States

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