The role of CD45 in T-cell activation--resolving the paradoxes?

D Alexander; M Shiroo; A Robinson; M Biffen; E Shivnan

doi:10.1016/0167-5699(92)90021-X

The role of CD45 in T-cell activation--resolving the paradoxes?

Immunol Today. 1992 Dec;13(12):477-81. doi: 10.1016/0167-5699(92)90021-X.

Authors

D Alexander¹, M Shiroo, A Robinson, M Biffen, E Shivnan

Affiliation

¹ Dept of Immunology, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.

PMID: 1463579
DOI: 10.1016/0167-5699(92)90021-X

Abstract

CD45 is one of the most abundant transmembrane glycoproteins expressed on the surface of haematopoietic cells. Despite the striking advances of the past few years in the understanding of the actions of CD45 at a molecular level, several paradoxes remain. This article argues that these paradoxes are more apparent than real, and suggests that CD45 plays a key role on the T-cell surface in regulating coupling of the antigen-receptor complex to intracellular signalling pathways.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

CD3 Complex / physiology
Leukocyte Common Antigens / physiology*
Lymphocyte Activation*
Phosphorylation
Protein Tyrosine Phosphatases / physiology
Protein-Tyrosine Kinases / physiology
Receptor Aggregation
Receptors, Antigen, T-Cell / physiology
Signal Transduction
T-Lymphocytes / immunology*
Tumor Cells, Cultured

Substances

CD3 Complex
Receptors, Antigen, T-Cell
Protein-Tyrosine Kinases
Leukocyte Common Antigens
Protein Tyrosine Phosphatases