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Oncogene. 2003 Nov 24;22(53):8543-67.

A decade of caspases.

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  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.


Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.

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