Arch Toxicol. 1992;66(8):598-601.

Increased urinary cadmium excretion and its relationship to urinary N-acetyl-beta-D-glucosaminidase activity in smokers.

Source

Department of Environmental Health Sciences, Tohoku University School of Medicine, Sendai, Japan.

Abstract

To assess the renal effects of low-level exposure to cadmium due to smoking we examined blood and urinary levels of cadmium and urinary excretions of N-acetyl-beta-D-glucosaminidase (NAG), beta 2-microglobulin (BMG) and metallothionein in 94 male workers aged 18-55 years. Both blood and urinary cadmium levels indicated excess exposure to cadmium caused by smoking. The urinary cadmium concentration ranged between 0.1 and 5.0 micrograms/g creatinine and increased significantly with age in the smokers. Neither urinary NAG nor BMG was increased in the smokers compared from non-smokers. A positive relationship between urinary cadmium and metallothionein was obtained not only in the smokers but also in the non-smokers. Furthermore, in the smokers urinary cadmium and metallothionein was positively related with urinary NAG. Since NAG in urine mostly originates from tubular cells by lysosomal exocytosis, the results may reflect an early cadmium effect on the lysosomal functions. Inhibitory effect of cadmium on the lysosomal degradation activities was discussed as a possible explanation of the positive relationship of urinary cadmium and metallothionein to urinary NAG.

PMID:: 1463395; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

CADMIUM, ELEMENTAL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Effects of cadmium and lead exposure on urinary N-acetyl-beta-D-glucosaminidase, beta 2-microglobulin and metallothionein of workers. [Asia Pac J Public Health. 1995]
Effects of cadmium and lead exposure on urinary N-acetyl-beta-D-glucosaminidase, beta 2-microglobulin and metallothionein of workers.
Kawada T, Tohyama C, Suzuki S. Asia Pac J Public Health. 1995; 8(2):91-4.
[Urinary N-acetyl-beta-D-glucosaminidase and its isoenzymes in smoking and non-smoking workers at copper foundry occupational co-exposed to arsenic cadmium and lead]. [Przegl Lek. 2008]
[Urinary N-acetyl-beta-D-glucosaminidase and its isoenzymes in smoking and non-smoking workers at copper foundry occupational co-exposed to arsenic cadmium and lead].
Milnerowicz H, Bizoń A, Witt K, Antonowicz-Juchniewicz J, Andrzejak R. Przegl Lek. 2008; 65(10):518-21.
[Select parameters of renal function in smokers in correlation with the exposure to cadmium]. [Przegl Lek. 2004]
[Select parameters of renal function in smokers in correlation with the exposure to cadmium].
Roszczenko A, Gałazyn-Sidorczuk M, Brzóska MM, Moniuszko-Jakoniuk J, Zwierz K. Przegl Lek. 2004; 61(4):348-50.
Review Indicators of renal effects of exposure to cadmium: N-acetyl-beta-D-glucosaminidase and others. [Sangyo Eiseigaku Zasshi. 1995]
Review Indicators of renal effects of exposure to cadmium: N-acetyl-beta-D-glucosaminidase and others.
Kawada T. Sangyo Eiseigaku Zasshi. 1995 Mar; 37(2):69-73.
Review Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors. [Biochimie. 2009]
Review Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors.
Nordberg GF, Jin T, Wu X, Lu J, Chen L, Lei L, Hong F, Nordberg M. Biochimie. 2009 Oct; 91(10):1282-5. Epub 2009 Jun 27.

See reviews... See all...

Cited by 1 PubMed Central article

Metallothionein gene expression in peripheral lymphocytes from cadmium-exposed workers. [Cell Stress Chaperones. 2001]
Metallothionein gene expression in peripheral lymphocytes from cadmium-exposed workers.
Lu J, Jin T, Nordberg G, Nordberg M. Cell Stress Chaperones. 2001 Apr; 6(2):97-104.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Increased urinary cadmium excretion and its relationship to urinary N-acetyl-bet...
Increased urinary cadmium excretion and its relationship to urinary N-acetyl-beta-D-glucosaminidase activity in smokers.
Arch Toxicol. 1992 ;66(8):598-601.

PubMed
Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric card...
Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus.
Gut. 2003 Dec ;52(12):1678-83.

PubMed
Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2...
Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload.
Clin Chem. 2003 Dec ;49(12):1981-8.

PubMed
Lowering the criterion for impaired fasting glucose will not provide clinical be...
Lowering the criterion for impaired fasting glucose will not provide clinical benefit.
Diabetes Care. 2003 Dec ;26(12):3329-30.

PubMed
Primary prevention of cardiovascular events with low-dose aspirin and vitamin E ...
Primary prevention of cardiovascular events with low-dose aspirin and vitamin E in type 2 diabetic patients: results of the Primary Prevention Project (PPP) trial.
Diabetes Care. 2003 Dec ;26(12):3264-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: