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Bioinformatics. 2003 Nov 22;19(17):2246-53.

A simple and efficient algorithm for gene selection using sparse logistic regression.

Author information

  • 1Department of Computer Science and Automation, Indian Institute of Science, Bangalore 560012, India.

Abstract

MOTIVATION:

This paper gives a new and efficient algorithm for the sparse logistic regression problem. The proposed algorithm is based on the Gauss-Seidel method and is asymptotically convergent. It is simple and extremely easy to implement; it neither uses any sophisticated mathematical programming software nor needs any matrix operations. It can be applied to a variety of real-world problems like identifying marker genes and building a classifier in the context of cancer diagnosis using microarray data.

RESULTS:

The gene selection method suggested in this paper is demonstrated on two real-world data sets and the results were found to be consistent with the literature.

AVAILABILITY:

The implementation of this algorithm is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml

SUPPLEMENTARY INFORMATION:

Supplementary material is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml

PMID:
14630653
[PubMed - indexed for MEDLINE]
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