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Curr Opin Immunol. 2003 Dec;15(6):660-7.

Genomic and proteomic analysis of multiple sclerosis. Opinion.

Author information

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. wrobins@stanford.edu

Abstract

Multiple sclerosis (MS) and other autoimmune diseases result from the dysregulation of genetic and proteomic programs. In MS, the loss of immune homeostasis leads to aberrant targeting and destruction of the myelin sheath, which manifests as the clinical syndrome of MS. The advent of technologies to perform large-scale analysis of mRNA transcript and protein expression will transform our understanding of the mechanisms underlying the initiation and progression of MS, and will yield new targets for therapeutic intervention.

PMID:
14630200
[PubMed - indexed for MEDLINE]
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