Leuk Res. 2004 Jan;28(1):35-42.

Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.

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Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32 street, 60-479 Poznan, Poland.

Abstract

The t(12;21)(p12;q22) is the most frequent chromosomal rearrangement observed in acute lymphoblastic leukaemia (ALL) and is associated with favourable prognosis and good response to initial treatment. The translocation-Ets-leukaemia (TEL) and AML1 genes are very often involved in chromosomal translocations in haematopoietic malignancies. This review presents the structure, roles of TEL and AML1 genes, and their proteins in haematopoiesis and in leukaemiogenesis as well. Aspects such as: the mechanism of translocation t(12;21)(p12;q22), function of TEL/AML1 fusion gene and chimeric protein, clinical significance of this abnormality and methods allowing to detect this translocation and its transcript are also discussed in this paper.

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Cited by 1 PubMed Central article

Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia. [BMC Genomics. 2007]
Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia.
Gandemer V, Rio AG, de Tayrac M, Sibut V, Mottier S, Ly Sunnaram B, Henry C, Monnier A, Berthou C, Le Gall E, et al. BMC Genomics. 2007 Oct 23; 8:385. Epub 2007 Oct 23.

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Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
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Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.

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