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J Med Genet. 2003 Nov;40(11):815-9.

A Y chromosomal influence on prostate cancer risk: the multi-ethnic cohort study.

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  • 1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Abstract

BACKGROUND:

A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk.

METHODS:

We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California.

RESULTS:

One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31).

CONCLUSIONS:

This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.

PMID:
14627670
[PubMed - indexed for MEDLINE]
PMCID:
PMC1735314
Free PMC Article
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