Are prenyl groups on proteins sticky fingers or gr...[Biochem J. 2003]

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1: Biochem J. 2003 Dec 1;376(Pt 2):e3-4. Links

Comment on:: Biochem J. 2003 Dec 1;376(Pt 2):449-56.

Are prenyl groups on proteins sticky fingers or greasy handles?

Magee AI, Seabra MC.

Section of Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. t.magee@imperial.ac.uk

This Commentary discusses the work of Dietrich et al. in this issue of the Biochemical Journal, which sheds new light on the biological roles of protein-bound prenyl groups by providing evidence that the alpha-subunit of the heterotrimeric G-protein transducin has a binding site for the geranylgeranyl group of the gamma-subunit.

PMID: 14627432 [PubMed - indexed for MEDLINE]

PMCID: PMC1223795

Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. [Biochem J. 2003]
Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like protein. [Biochemistry. 2004]
The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic. [Biochemistry. 2006]
Isoprenylated proteins. [Cell Mol Life Sci. 2006]
Over-expression of a truncated Arabidopsis thaliana heterotrimeric G protein gamma subunit results in a phenotype similar to alpha and beta subunit knockouts. [Gene. 2007]
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Are prenyl groups on proteins sticky fingers or greasy handles?

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