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Acta Neurol Belg. 2003 Sep;103(3):159-63.

Donepezil in the treatment of mild to moderate Alzheimer's disease: report of a Belgian multicenter study.

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  • 1Department of Neurology, Ghent University Hospital.


In this report the results of a Belgian multicenter 24-week open-label study with donepezil in the treatment of mild to moderate Alzheimer's disease are described. Efficacy and safety were evaluated in a sample of 200 patients recruited in 25 Belgian centers. No significant changes could be found in cognition and behaviour over this 6-month period. Changes in daily functioning were small. Safety data were comparable to those reported in international trials. These results suggest that the findings of more robust double-blind, placebo-controlled studies can be confirmed in real life situations.

[PubMed - indexed for MEDLINE]
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