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Brain Res Mol Brain Res. 2003 Nov 26;119(2):213-5.

COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

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  • 1Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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  • Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):136.


We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.

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