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Am J Ther. 2003 Nov-Dec;10(6):415-22.

Endothelium and hypertensive disorders in pregnancy.

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  • 1Unit of Clinical Pharmacology, José Maria Vargas School of Medicine, Central University of Venezuela, Caracas, Venezuela.


Pregnancy-induced hypertension is one of the complications that obstetricians fear most due to its sudden appearance, its changing clinical presentation, its rapid evolution, and its association with high fetal and maternal morbidity and mortality. Because of these reasons, preeclampsia has been studied widely. But although the search for answers to many questions about its etiopathogenesis and physiopathology has led to numerous researches, after many years of studies and efforts there still exist obscure and enigmatic aspects about them. Today, various risk factors for the development of this entity have been identified, and a combination of different hypotheses has been proposed to try to find an approximation to the real solution for this problem, which could probably lead to better therapeutic management.

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