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Gerontology. 2003 Nov-Dec;49(6):380-3.

Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity.

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  • 1Psychiatric Clinic, University of Basel, Basel, Switzerland. esavaskan@datacomm.ch

Abstract

BACKGROUND:

beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol.

OBJECTIVE:

The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Abeta-induced neurotoxicity.

METHODS:

The neuroprotective capacity against Abeta-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances.

RESULTS:

Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione.

CONCLUSION:

Our findings suggest that red wine may be neuroprotective through the actions of resveratrol.

Copyright 2003 S. Karger AG, Basel

PMID:
14624067
DOI:
73766
[PubMed - indexed for MEDLINE]
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