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1: FEBS Lett. 2003 Nov 20;554(3):410-6.Click here to read Links

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.

Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ.

Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, St. Dunstan's Road, London W6 8RP, UK. e.tarttelin@imperial.ac.uk

We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.

PMID: 14623103 [PubMed - indexed for MEDLINE]