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Mol Microbiol. 2003 Oct;50(2):495-509.

SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli.

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  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


SetB was identified as a high-copy suppressor of the partition defect of a mutation in parC, encoding one of the subunits of topoisomerase IV. Deletion of this integral inner membrane protein causes a delay in chromosome segregation, whereas its overproduction causes nucleoid disintegration and stretching, leading to a cell division defect. setB deletion mutants also exhibit a synthetic phenotype when combined with mutations that delete the C-terminal motor domain of the septal ring protein FtsK. SetB localizes in the cell as a helix and interacts with MreB, the bacterial actin homologue, which also forms a helix. These observations suggest that there may be a link between chromosome segregation and cellular infrastructure.

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