Magn Reson Imaging. 1992;10(6):975-81.

Noninvasive in vivo 13C-NMR spectroscopy of a 13C-labeled xenobiotic in the rat.

Lanens D, Muller HJ, Van de Vyver F, de Cock-Bunning T, Spanoghe M, Van der Linden A, Mulder GJ, Dommisse R, Lugtenburg J.

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Research Group for Biomedical NMR, University of Antwerp, Wilrijk, Belgium.

Abstract

This study demonstrates that the xenobiotic product, 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloro-3-13C-propane can be monitored in the liver of an intact animal by in vivo 13C surface coil NMR spectroscopy after intraperitoneal administration. The carbon-13 label could be detected after a single dose of only 200 mg/kg of the product. The intrahepatic changes of the signal intensity of the labeled product were monitored as a function of time. No signals corresponding to metabolites could be detected.

PMID:: 1461095; [PubMed - indexed for MEDLINE]

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