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Am J Geriatr Psychiatry. 2003 Nov-Dec;11(6):678-82.

MRI lesion severity and mortality in geriatric depression.

Author information

  • 1Department of Psychaitry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. steff001@mc.duke.edu

Abstract

OBJECTIVE:

The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients.

METHOD:

They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensity (PVH), and subcortical gray-matter hyperintensity (SGH) ratings in 259 subjects.

RESULTS:

DWMH and PVH were significantly associated with mortality initially, and, in final modeling, DWMH remained significant.

CONCLUSION:

These findings suggest that there is a relationship between cerebrovascular disease severity and mortality among depressed patients. More studies, with larger sample sizes, comparing depressed patients and control subjects are needed to further elucidate this relationship.

PMID:
14609809
[PubMed - indexed for MEDLINE]
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