Send to

Choose Destination
See comment in PubMed Commons below
Psychopharmacol Bull. 2003 Summer;37(3):84-9.

Acute cortisol administration triggers craving in individuals with cocaine dependence.

Author information

  • 1Behavioral Psychopharmacology Research Laboratory, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.


Stress is often mentioned as a factor in the development of drug abuse. Twelve cocaine dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses, in a double-blind, counterbalanced fashion. Self-reports of mood states were collected prior to, during, and 20 minutes after each bolus was administered. Cortisol produced significant increases in craving while cocaine significantly elevated all subjective ratings (ie, craving, high, rush, and low). These pilot data suggest that cortisol can induce a state that is associated with drug abuse.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk