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Org Lett. 2003 Nov 13;5(23):4257-9.

A mild and efficient one-step synthesis of quinolines.

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  • 1Department of Dermatology, The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.

Abstract

[reaction: see text] The Friedländer synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl(2) and ZnCl(2) to effect the reaction.

PMID:
14601974
[PubMed]
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