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Acta Paediatr Suppl. 2003 Sep;91(441):80-1.

Pro- and pre-biotics administration in preterm infants: colonization and influence on faecal flora.

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  • 1Department of Paediatrics and Neonatology, University of Milan, Italy.


Prolonged administration of probiotic in preterm babies induce a rise of specific IgA and IgM antibodies against probiotic. This fact explains why presence of living germs in stools almost disappeared in spite of continuous administration. However some positive influences were observed: decreased ratio of aerobic/anaerobic. Increased ratio of gram +/gram - germs. Prebiotic administration induces after 28 days a significant increase of faecal bifidobacteria and frequency and consistency of stools were more similar to those observed in subjects fed with human milk.

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