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Am J Psychiatry. 2003 Nov;160(11):2060-2.

A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings.

Author information

  • 1Department of Psychology, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Abstract

OBJECTIVE:

This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings.

METHOD:

Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests.

RESULTS:

The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest.

CONCLUSIONS:

Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings.

PMID:
14594759
[PubMed - indexed for MEDLINE]
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