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Clin Liver Dis. 2003 Nov;7(4):759-77, vi.

Antimitochondrial and other autoantibodies.

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  • 1Institute of Liver Studies, King College Hospital, Denmark Hill Campus, London SE5 9RS, UK.


Primary biliary cirrhosis (PBC) is characterized by the presence of high-titer disease specific autoantibodies directed against mitochondrial antigens (AMA) of the inner mitochondrial membrane, that are members of the 2-oxo acid complex. Among numerous other autoantibodies found in PBC the focus of ongoing studies is on the PBC-specific anti-nuclear antibodies, that are of diagnostic and clinical relevance since they can be used as a 'positive tool' in the diagnosis of AMA-negative PBC while at the same time identifying a subgroup of patients with more advanced liver disease.

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