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1: EMBO Rep. 2003 Nov;4(11):1038-42.Click here to read Click here to read Links

Potassium channel regulation.

Campbell JD, Sansom MS, Ashcroft FM.

University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK.

The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional differences, we have constructed a molecular model of the NBD dimer of human SUR1. We discuss the experimental data in the context of this model, and show how the model can be used to design experiments aimed at elucidating the relationship between the structure and function of the KATP channel.

PMID: 14593442 [PubMed - indexed for MEDLINE]

PMCID: PMC1326373

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  • Potassium (Glu-K® , K+ 10® , K+ 8® , ...)

    Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...

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