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Nat Genet. 2003 Nov;35(3):213-4.

Maintenance of heterochromatin by RNA interference of tandem repeats.

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  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. martiens@cshl.org

Abstract

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

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