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Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8.

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

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  • 1Program in Cell Biology and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


Heat shock protein 90 (Hsp90) is a molecular chaperone necessary for maintaining oncogenic transformation. There is substantial interest in developing novel agents that bind to the N-terminal of the chaperone. Here we report the synthesis and characterization of two fluorescent Hsp90 inhibitors and probe their use in an Hsp90 fluorescent polarization assay.

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