Clin Rheumatol. 1992 Sep;11(3):341-5.

Anti-dsDNA and Sm autoantibodies in systemic lupus erythematosus.

Martínez-Cordero E, Martínez-Miranda E, Negrete-García MC, Padilla A, Aguilar León DE.

Source

Departamento de Investigación, Hospital 20 de Noviembre, ISSSTE, México.

Abstract

During the present study the coincidence of anti-dsDNA and Sm antibodies was detected in 16 percent of 51 consecutive SLE patients. These antibodies were detected by the standard indirect immunofluorescence and Ouchterlony tests. All patients with anti-dsDNA and Sm antibodies showed disease activity, including renal, CNS and pulmonary disease. We excluded a cross reactivity of these antibodies by ELISA, using competitive experiments with dsDNA and Sm antigens. The results support the presence of multiple autoantibody production during SLE activity, and suggest that different mechanisms may underlie the induction and regulation of both autoantibodies.

PMID:: 1458781; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

EBSCO

Medical

Lupus - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies. [Arthritis Res Ther. 2005]
Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies.
Mahler M, Fritzler MJ, Blüthner M. Arthritis Res Ther. 2005; 7(1):R19-29. Epub 2004 Nov 10.
Anti-Sm: its predictive value in systemic lupus erythematosus. [Clin Rheumatol. 1993]
Anti-Sm: its predictive value in systemic lupus erythematosus.
Janwityanuchit S, Verasertniyom O, Vanichapuntu M, Vatanasuk M. Clin Rheumatol. 1993 Sep; 12(3):350-3.
Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis. [Ann Rheum Dis. 2003]
Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis.
Alba P, Bento L, Cuadrado MJ, Karim Y, Tungekar MF, Abbs I, Khamashta MA, D'Cruz D, Hughes GR. Ann Rheum Dis. 2003 Jun; 62(6):556-60.
Review Pathogenic significance and diagnostic value of lupus autoantibodies. [Int Arch Allergy Immunol. 1993]
Review Pathogenic significance and diagnostic value of lupus autoantibodies.
Tomer Y, Buskila D, Shoenfeld Y. Int Arch Allergy Immunol. 1993; 100(4):293-306.
Review Antinuclear antibodies in autoimmune disease. Significance and pathogenicity. [Med Clin North Am. 1985]
Review Antinuclear antibodies in autoimmune disease. Significance and pathogenicity.
Harmon CE. Med Clin North Am. 1985 May; 69(3):547-63.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Anti-dsDNA and Sm autoantibodies in systemic lupus erythematosus.
Anti-dsDNA and Sm autoantibodies in systemic lupus erythematosus.
Clin Rheumatol. 1992 Sep ;11(3):341-5.

PubMed
Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic vir...
Effects of homeopathic arsenic on tobacco plant resistance to tobacco mosaic virus. Theoretical suggestions about system variability, based on a large experimental data set.
Homeopathy. 2003 Oct ;92(4):195-202.

PubMed
Methods of determining plasma and tissue binding of drugs. Pharmacokinetic conse...
Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences.
Clin Pharmacokinet. 1992 Dec ;23(6):449-68.

PubMed
Image-based functional neurosurgery.
Image-based functional neurosurgery.
Clin Neurosurg. 1992 ;39:314-30.

PubMed
[Magnetoencephalography as a tool for a clinician].
[Magnetoencephalography as a tool for a clinician].
Duodecim. 2003 ;119(17):1645-53.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Anti-dsDNA and Sm autoantibodies in systemic lupus erythematosus.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information