Vitamin C depletion and pressure sores in elderly patients with femoral neck fracture

BMJ. 1992 Oct 17;305(6859):925-7. doi: 10.1136/bmj.305.6859.925.

Abstract

Objective: To evaluate the contribution of specific nutritional deficiencies (as indicated by zinc; vitamin A, C, and E; albumin; and haemoglobin concentrations) to the risk of pressure sores.

Design: Observational cohort study.

Setting: St James's University Hospital, Leeds.

Subjects: 21 elderly patients presenting consecutively to the orthopaedic unit with femoral neck fracture.

Main outcome measure: Full thickness epidermal break over a pressure bearing surface.

Results: 10 patients (48%) developed a pressure sore during their hospital stay. Indices of zinc status and concentrations of albumin, haemoglobin, and vitamins A and E were similar in patients who developed a pressure sore and those who did not. Mean leucocyte vitamin C concentration, however, was 6.3 (SD 2.2) micrograms/10(8) cells in patients who developed a pressure sore as compared with 12.8 (4.6) micrograms/10(8) cells in patients who did not.

Conclusions: Low concentrations of leucocyte vitamin C appear to be associated with subsequent development of pressure sores in elderly patients with femoral neck fractures.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Ascorbic Acid Deficiency / complications*
  • Cohort Studies
  • Female
  • Femoral Neck Fractures / complications*
  • Humans
  • Leukocytes / chemistry
  • Male
  • Pressure Ulcer / etiology*
  • Risk Factors
  • Vitamin A Deficiency / complications
  • Vitamin E Deficiency / complications
  • Zinc / deficiency

Substances

  • Zinc