Mol Cell. 2003 Oct;12(4):799-800.

Better late than never for repair of miscoding lesions within a transcribed template.

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Centre of Molecular Biology and Neuroscience and Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, The National Hospital, 0027 Oslo, , Norway.

Abstract

Transcription does not always stall at base damage in DNA and can create mutated transcripts from miscoding lesions. In this issue of Molecular Cell, present genetic analysis of E. coli to indicate that the highly mutagenic purine modification, 8-oxoguanine, is subject to transcription-coupled repair despite transcriptional bypass and generation of mutant transcripts.

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Mol Cell. 2003 Oct;12(4):959-70.

PMID:: 14580331; [PubMed - indexed for MEDLINE]

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