Bioessays. 2003 Nov;25(11):1031-4.

Alternative splicing and evolution.

Source

EMBL, Heidelberg, Germany. boue@embl.de

Abstract

Alternative splicing is a critical post-transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms. It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint.

PMID:: 14579243; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

The effect of intron length on exon creation ratios during the evolution of mammalian genomes. [RNA. 2008]
The effect of intron length on exon creation ratios during the evolution of mammalian genomes.
Roy M, Kim N, Xing Y, Lee C. RNA. 2008 Nov; 14(11):2261-73. Epub 2008 Sep 16.
Identify alternative splicing events based on position-specific evolutionary conservation. [PLoS One. 2008]
Identify alternative splicing events based on position-specific evolutionary conservation.
Chen L, Zheng S. PLoS One. 2008 Jul 30; 3(7):e2806. Epub 2008 Jul 30.
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons. [Mol Biol Evol. 2005]
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons.
Cusack BP, Wolfe KH. Mol Biol Evol. 2005 Nov; 22(11):2198-208. Epub 2005 Jul 27.
Review Quantitative regulation of alternative splicing in evolution and development. [Bioessays. 2009]
Review Quantitative regulation of alternative splicing in evolution and development.
Irimia M, Rukov JL, Roy SW, Vinther J, Garcia-Fernandez J. Bioessays. 2009 Jan; 31(1):40-50.
Review Evolution of alternative splicing: deletions, insertions and origin of functional parts of proteins from intron sequences. [Trends Genet. 2003]
Review Evolution of alternative splicing: deletions, insertions and origin of functional parts of proteins from intron sequences.
Kondrashov FA, Koonin EV. Trends Genet. 2003 Mar; 19(3):115-9.

See reviews... See all...

Cited by 29 PubMed Central articles

BEAT: Bioinformatics Exon Array Tool to store, analyze and visualize Affymetrix GeneChip Human Exon Array data from disease experiments. [BMC Bioinformatics. 2012]
BEAT: Bioinformatics Exon Array Tool to store, analyze and visualize Affymetrix GeneChip Human Exon Array data from disease experiments.
Consiglio A, Carella M, De Caro G, Delle Foglie G, Giovannelli C, Grillo G, Ianigro M, Licciulli F, Palumbo O, Piepoli A, et al. BMC Bioinformatics. 2012 Mar 28; 13 Suppl 4:S21. Epub 2012 Mar 28.
Interrogation of alternative splicing events in duplicated genes during evolution. [BMC Genomics. 2011]
Interrogation of alternative splicing events in duplicated genes during evolution.
Chen TW, Wu TH, Ng WV, Lin WC. BMC Genomics. 2011 Nov 30; 12 Suppl 3:S16. Epub 2011 Nov 30.
Ontogenomic study of the relationship between number of gene splice variants and GO categorization. [Bioinformatics. 2010]
Ontogenomic study of the relationship between number of gene splice variants and GO categorization.
Kahn AB, Zeeberg BR, Ryan MC, Jamison DC, Rockoff DM, Pommier Y, Weinstein JN. Bioinformatics. 2010 Aug 15; 26(16):1945-9. Epub 2010 Jul 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Alternative splicing and evolution.
Alternative splicing and evolution.
Bioessays. 2003 Nov ;25(11):1031-4.

PubMed
Dialysis leg cramps. Efficacy of quinine versus vitamin E.
Dialysis leg cramps. Efficacy of quinine versus vitamin E.
ASAIO J. 1992 Jul-Sep ;38(3):M481-5.

PubMed
Recombinant human estrogen, androgen and progesterone receptors for detection of...
Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors.
Anal Bioanal Chem. 2004 Feb ;378(3):664-9. Epub 2003 Oct 25 .

PubMed
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable...
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation.
Nat Struct Biol. 2003 Dec ;10(12):1054-7. Epub 2003 Oct 26 .

PubMed
Interaction of reelin signaling and Lis1 in brain development.
Interaction of reelin signaling and Lis1 in brain development.
Nat Genet. 2003 Nov ;35(3):270-6. Epub 2003 Oct 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: