Send to:

Choose Destination
See comment in PubMed Commons below
Nat Genet. 2003 Nov;35(3):219-20. Epub 2003 Oct 26.

Human Alu element retrotransposition induced by genotoxic stress.

Author information

  • 1Biological Sciences Division and Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.

Erratum in

  • Nat Genet. 2003 Dec;35(4):377.


Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk