Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Reprod Biol Endocrinol. 2003 Oct 7;1:68.

Early events in ovarian oncogenesis.

Author information

  • Ovarian Cancer Program, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA, USA. DI_Cvetkovic@fccc.edu

Abstract

Ovarian cancer represents the most lethal of the gynecological neoplasms. The molecular and genetic events associated with early ovarian oncogenesis are still largely unknown, thus contributing to the lack of reliable biomarkers for disease detection. Since the majority of ovarian tumors are diagnosed at an advanced stage, the availability of early ovarian cancer tissue samples for molecular analyses is very limited. In this review, problems encountered in the study of early ovarian cancer are presented, along with the controversies concerning precursor lesions and stepwise progression towards ovarian malignancy. Experimental modeling in the development of ovarian cancer is also described, as well as genetic and epigenetic alterations associated with early ovarian cancer. Lastly, examples of technological advances in the study of early ovarian cancer are discussed. Hopefully, the increasing knowledge about molecular and genetic events involved in the early stages of ovarian tumorigenesis will provide the basis for management of ovarian cancer in the future.

PMID:
14577833
[PubMed - indexed for MEDLINE]
PMCID:
PMC239895
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk