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Science. 2003 Nov 28;302(5650):1581-4. Epub 2003 Oct 23.

Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.

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  • 1Molecular Oncology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex.

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PMID:
14576442
[PubMed - indexed for MEDLINE]
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