Science. 2003 Oct 24;302(5645):643-6.

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.

King MC, Marks JH, Mandell JB; New York Breast Cancer Study Group.

Source

Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA. mcking@u.washington.edu

Abstract

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset.

Comment in

Breast cancer risks for BRCA1/2 carriers. [Science. 2004]
Breast cancer risks for BRCA1/2 carriers.Wacholder S, Struewing JP, Hartge P, Greene MH, Tucker MA. Science. 2004 Dec 24; 306(5705):2187-91; author reply 2187-91.
Breast cancer risks for BRCA1/2 carriers. [Science. 2004]
Breast cancer risks for BRCA1/2 carriers.Easton DF, Hopper JL, Thomas DC, Antoniou A, Pharoah PD, Whittemore AS, Haile RW. Science. 2004 Dec 24; 306(5705):2187-91; author reply 2187-91.
Cancer. A risky business--assessing breast cancer risk. [Science. 2003]
Cancer. A risky business--assessing breast cancer risk.Levy-Lahad E, Plon SE. Science. 2003 Oct 24; 302(5645):574-5.

PMID:: 14576434; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous

See the articles recommended by F1000Prime's Faculty of 5,000 renowned researchers and clinicians, assisted by 5,000 associates. - F1000

Supplemental Content

Save items

Related citations in PubMed

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. [Am J Hum Genet. 2003]
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, et al. Am J Hum Genet. 2003 May; 72(5):1117-30. Epub 2003 Apr 3.
The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. [Cancer Epidemiol Biomarkers Pr...]
The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.
Satagopan JM, Offit K, Foulkes W, Robson ME, Wacholder S, Eng CM, Karp SE, Begg CB. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):467-73.
Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population. [Proc Natl Acad Sci U S A. 2006]
Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population.
Simchoni S, Friedman E, Kaufman B, Gershoni-Baruch R, Orr-Urtreger A, Kedar-Barnes I, Shiri-Sverdlov R, Dagan E, Tsabari S, Shohat M, et al. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3770-4. Epub 2006 Feb 28.
Review Future possibilities in the prevention of breast cancer: intervention strategies in BRCA1 and BRCA2 mutation carriers. [Breast Cancer Res. 2000]
Review Future possibilities in the prevention of breast cancer: intervention strategies in BRCA1 and BRCA2 mutation carriers.
Eeles RA. Breast Cancer Res. 2000; 2(4):283-90. Epub 2000 May 25.
Review Breast cancer and ovarian cancer genetics. [J Long Term Eff Med Implants. ...]
Review Breast cancer and ovarian cancer genetics.
Edlich RF, Winters KL, Lin KY. J Long Term Eff Med Implants. 2005; 15(5):533-45.

See reviews... See all...

Cited by over 100 PubMed Central articles

Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population. [PLoS Genet. 2013]
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
Haiman CA, Han Y, Feng Y, Xia L, Hsu C, Sheng X, Pooler LC, Patel Y, Kolonel LN, Carter E, et al. PLoS Genet. 2013 Mar; 9(3):e1003419. Epub 2013 Mar 28.
Prevalence of BRCA1 mutations in familial and sporadic greek ovarian cancer cases. [PLoS One. 2013]
Prevalence of BRCA1 mutations in familial and sporadic greek ovarian cancer cases.
Stavropoulou AV, Fostira F, Pertesi M, Tsitlaidou M, Voutsinas GE, Triantafyllidou O, Bamias A, Dimopoulos MA, Timotheadou E, Pectasides D, et al. PLoS One. 2013; 8(3):e58182. Epub 2013 Mar 11.
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers. [BMC Cancer. 2013]
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers.
Guinan EM, Hussey J, McGarrigle SA, Healy LA, O'Sullivan JN, Bennett K, Connolly EM. BMC Cancer. 2013 Mar 21; 13:138. Epub 2013 Mar 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
MedGen (Bookshelf cited)
Related records in MedGen based on citations in GeneReviews and Medical Genetics Summaries
MedGen (OMIM)
Related information in MedGen (OMIM)
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.
Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.
Science. 2003 Oct 24 ;302(5645):643-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.

Source

Abstract

Comment in

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information