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1: Biol Psychiatry. 1992 Oct 15;32(8):705-11.Click here to read Links
Comment in:
Biol Psychiatry. 1993 Oct 15;34(8):587.

Melatonin and jet lag: confirmatory result using a simplified protocol.

Claustrat B, Brun J, David M, Sassolas G, Chazot G.

Service de Radiopharmacie et Radioanalyse, Hôpital Neuro-Cardiologique, Lyon, France.

This study replicates the alleviation of jet-lag with melatonin in a simplified protocol for eastward flight. At 22-n hr (n is the time-lag between the North American departure point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n = 15) on the day of the return flight and for 3 consecutive days. On day 8, self-ratings significantly discriminated between melatonin and placebo for global treatment efficacy, morning fatigue, and evening sleepiness.

PMID: 1457626 [PubMed - indexed for MEDLINE]