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Arch Toxicol. 2003 Oct;77(10):591-3. Epub 2003 Sep 17.

Acetaldehyde adducts in the brain of alcoholics.

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  • 1Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama Hamamatsu-shi, 431-3192 Shizuoka, Japan.


Acetaldehyde binds to some proteins and becomes a Schiff base. It is assumed that after the consumption of ethanol the acetaldehyde binds to the proteins to form adducts, and such acetaldehyde adducts are associated with organ diseases. We investigated the detection of acetaldehyde adducts in the brain region of a human alcoholics. Brain samples collected from an alcoholic autopsied case were used. Determination of acetaldehyde adducts was performed using a fluorescence immmunohistochemical staining method with antibodies against acetaldehyde adducts. We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics.

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