-
Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.
Lindsley F. Kimball Research Institute, New York Blood Center, New York 10021.
Similarities between the N-terminal regions of the three subunits of the clotting protein fibrinogen--(alpha beta gamma)2--suggest that they evolved from a common progenitor. However, to date no human alpha chain has been found with the strong C-terminal homology shared by the beta and gamma chains. Here we examine the natural product of a novel fibrinogen alpha chain transcript bearing a separate open reading frame that supplies the missing C-terminal homology to the other chains. Additional splicing leads to the use of this extra sequence as a sixth exon elongating the alpha chain by 35%. Since the extended alpha chain (alpha E) is assembled into fibrinogen molecules and its synthesis is enhanced by interleukin-6, it suggests participation in both the acute phase response and normal physiology.
PMID: 1457396 [PubMed - indexed for MEDLINE]
-
Cited by 4 PubMed Central articles
-
Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains.
Lee EC, Yu SY, Hu X, Mlodzik M, Baker NE.
Genetics. 1998 Oct; 150(2):663-73.
[Genetics. 1998]
-
Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.
Spraggon G, Applegate D, Everse SJ, Zhang JZ, Veerapandian L, Redman C, Doolittle RF, Grieninger G.
Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9099-104.
[Proc Natl Acad Sci U S A. 1998]
-
Fib420: a normal human variant of fibrinogen with two extended alpha chains.
Fu Y, Grieninger G.
Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2625-8.
[Proc Natl Acad Sci U S A. 1994]
- » See all...