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[Tetracyclines, sulfonamides and metronidazole]
[Article in Spanish]
Servicio de Microbiología. Hospital Donostia. San Sebastián. España.
Tetracyclines form a group of natural and semisynthetic products that acts inhibiting the bacterial protein synthesis. They are bacteriostatic agents, exhibiting activity against a wide range of organisms, but they are at the present of limited use because of their acquired resistance. Doxycycline is currently the most frequently used tetracycline in human medicine and it is included in the List of Essential Medicines of the World Health Organization. Sulfonamides are synthetic, broad-spectrum bacteriostatic antibiotics. They were the first effective systemic antimicrobial agents. Their mode of action is based on the inhibition of DNA synthesis. Due to their toxicity and high adquired resistance their use is currently very low. Metronidazole is the main compound of 5-nitroimidazole family. It is a very active bactericidal antibiotic against anaerobic and some microaerophilic bacteria and it is still very useful in the treatment of bacterian and parasitic infections.
PMID: 14572387 [PubMed - indexed for MEDLINE]
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Cited by 1 PubMed Central article
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Snake Venom: Any Clue for Antibiotics and CAM?
de Lima DC, Alvarez Abreu P, de Freitas CC, Santos DO, Borges RO, Dos Santos TC, Mendes Cabral L, Rodrigues CR, Castro HC.
Evid Based Complement Alternat Med. 2005 Mar; 2(1):39-47.
[Evid Based Complement Alternat Med. 2005]
Patient Drug Information
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Tetracycline (Helidac Therapy® as a combination product containing Tetracycline, Metronidazole, and Bismuth subsalicylate, Sumycin® , Sumycin® Syrup)
Tetracycline, is used to treat bacterial infections, including pneumonia and other respiratory tract infections; acne; infections of skin, genital and urinary systems; and the infection that causes stomach ulcers (Helico...
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Doxycycline (Doryx® , Monodox® , Vibramycin® Calcium Syrup, ...)
Doxycycline is used to treat bacterial infections, including pneumonia and other respiratory tract infections; Lyme disease; acne; infections of skin, genital, and urinary systems; and anthrax (after inhalational exposur...