Handheld computers, also known as personal digital assistants (PDAs), are becoming an increasingly valuable aid to physicians at the point of care. We review the use of handheld computers and their impact in clinical practice and medical education. Clinicians commonly use PDAs to access patient data and as a clinical reference tool. In medical education, handheld computers are most frequently used to track patient encounters and procedures done during medical school rotations and residency training. This report describes some interesting applications for present and future use of PDAs in inpatient care and medical education. Physicians and educational programs not using PDAs may wish to consider incorporating this technology.